The Pro12Ala Polymorphism in Prediabetes and Type 2 Diabetes in a Sample of the Bulgarian Population

Issue: 1/2017

Author: Zaharieva, Emanuela Tsv. 1, Kamenov, Zdravko A.1, Savov, Alexey S.2

1 Alexandrovska University Hospital, Clinic of Endocrinology, Medical University, Sofia
2 University Hospital of Obstetrics and Gynecology “Maichin Dom”, National Genetic Laboratory,
Medical University, Sofia


The Pro12Ala polymorphism of the PPARG2 gene, encoding peroxisome proliferator-activated receptor gamma, is related to a reduced risk of type 2 diabetes (T2D) and better insulin sensitivity.
The aim of the current study was to estimate the association between the polymorphism and the prevalence of T2D and prediabetes in a sample of the Bulgarian population.
Subjects and methods: The project included 114 patients with T2D, 29 people with prediabetes and 27 control subjects. Genetic analysis was performed with polymerase chain reaction and restriction analysis.
Results: The prevalence of heterozygote genotype among T2D patients and prediabetic subjects did not differ significantly compared to controls but it was more frequently observed in prediabetes than in T2D (34,5% versus 17,5%, p=0,045). In neither group did the heterozygote genotype associate with a significant difference in anthropometric and metabolic parameters.
Conclusion: In the current study Pro12Ala polymorphism was not associated with risk of T2D or prediabetes but it may be protective in the evolution of the prediabetic state.

Key words: Pro12Ala polymorphism, Type 2 diabetes, Prediabetes

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Journal of the Bulgarian Society of Endocrinology

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