Adiponectin and Markers of Insulin Resistance in Primary Aldosteronism
Issue: 2/2010
Author: Joanna Matrozova, Sabina Zacharieva, Atanaska Elenkova, Georgi Kirilov
Abstract:
Introduction. Patients with primary aldosteronism (PA) have a higher prevalence of cardiovascular complications than patients with essential hypertension (EH). This increased cardiovascular risk could be due to carbohydrate disorders in PA or to some other mechanisms of insulin resistance.
Aim. The aim of this study was to compare insulin resistance parameters (immunoreactive insulin (IRI), HOMA-index and adiponectin levels between patients with PA and control subjects with EH.
Patients and methods. The study population consisted of 22 patients with PA and 35 controls with EH, matched for age and sex. Aldosterone, plasma renin activity (PRA) and adiponectin were measured by radioimmunoassay, and IRI- by immunoradiometric assay. In statistical analysis we used Сhi-square test for categorical data and Student’s t-test or test of Mann- Whitney for continuous data as well as correlation analysis.
Results. There was no significant difference in terms of IRI (5,7 [3,2-11,5] vs 7,4 [4,2-13,1] mIU/l, р= 0,28), HOMA-index (1,60 [0,78-3,17] vs 1,44 [0,82-3,14], p=0,81) and adiponectin levels (11,2 [6,77-18,25] vs 10,8 [7,2-18] mg/l, p=0,57) between PA and EH.
Conclusions. We didn’t find any significant difference in the insulin resistance parameters and adiponectin levels between patients with PA and controls with EH. The impairement of carbohydrate metabolism or the presence of endothelial dysfunction in patients with PA compared with patients with EH is not confirmed.
Keywords: primary aldosteronism, essential hypertension, insulin resistance, adiponectin.
