Issue 4/1998

Molecular Mechanisms of Hormonal Transmembrane Signalling

Issue: 4/1998 Author: M. S. Setchenska, T. Y. Christova, Z. S. Diankova, Sv. A. Alexandrov, Institute of Biophysics, Bulgarian Academy of Sciences – Sofia Abstract: Different hormones mediate their biological responses by binding to the receptors on the cell membrane. These trigger a cascade of events that lead to generation of second messengers of the signal transduction. […]


Biochemical Markers of Bone Metabolism

Issue: 4/1998 Author: S. Simeonov, E. Kumchev*, E. Enchev, S. Tsvetkova*', Higher Medical Institute – Plovdiv Clinic of Endocrinology *Clinic of Nephrology Chair of X – Ray and Radiology** Abstract:   Different noninvasive methods for the assesment of bone metabolism have been introduced in clinical practice in recent years. Together with the new densitometers, allowing exact evaluation […]


Hypoglycemic Episodes in Diabetic Children

Issue: 4/1998 Author: V. Tzaneva, Clinic of Endocrinology and Gastroenterology Department of Pediatrics, Medical University – Varna Abstract:   Hypoglycemia is the most common complication of Type 1 Diabetes. The incidence rate, etiology and clinical characteristics of hypoglycemia were studied in 64 diabetic children followed-up by the author for 1-14 years after the onset of their disease. […]


Oxidative Stress in Diabetic Patients Treated with Monocomponent Pork Insulins

Issue: 4/1998 Author: N. Ovcharova, P. Angelova-Gateva, D. Koev, G. Dakovska, Clinical Center of Endocrinology and Gerontology – Sofia Abstract:    Thirty diabetic patients of both sexes with mean age 59,6 years were investigated before and after 45 days therapy with monocomponent pork insulins. With IDDM were 3 patients and with NIDDM and secondary failure to sulphonylurea […]


Effect of Glucotrol XL on Glyeaemic Control in Non-insulin Dependent Diabetic Patients

Issue: 4/1998 Author: M. Petkova, Diabetes Center, Orthodox Polyclinic „St. Luca" – Sofia Abstract:    Glucotrol XL® is a new therapeutic formula, delivering the short-acting sulfanylurea glipizide at an effective therapeutic plasma level throughout a 24-hour period. To eveluate the efficacy and safety of Glucotrol XL® on the glyeaemic control in non-insulin dependent diabetic patients (NIDDM) an […]


Treatment of Severe Diabetic Neuropathy with α-lipoic Acid

Issue: 4/1998   Author: Tsv. Taknova, D. Koev, L. Dakovska, R. Savova*, I. Litvinenko*, B. Angelova*, K. Koprivarova*, P. Angelova, Clinic of Diabetology, Clinical Center of Endocrinology and Gerontology, Medical University – Sofia, * Clinic of Paediatrics, Medical University – Sofia   Abstract:    20 patients with type1 diabetes and severe diabetic neuropathy, of mean age […]


A Case-report of Wolfram Syndrome

Issue: 4/1998 Author: M. Boyanov, A. Angelinin, P. Popivanov, M. Protich, Clinic of Endocrinology, Medical University – Sofia Abstract:    We describe a rare syndrome in clinical practice, comprising insulin-dependent diabetes mellitus, neurogenic diabetes insipidus, optic atrophy and sensoneural deafness. A short rewiew is presented on its etiology, pathophysiology and natural course. The clinical findings, hormonal results […]


Osteoporosis – Diagnosis, Prevention and Treatment

Issue: 4/1998 Author: A.-M. Borissova, Clinical Center of Endocrinology and Gerontology – Sofia Abstract:    Osteoporosis is a chronic, progressive metabolic bone disease, which is preventable and treatable. Osteoporosis is a very important public health problem, because of its „epidemical" occurrance in middle-age women and the osteoporosis-related fractures. It is necessary to design and implement effective programs […]


Endocrinologia bg-flag

Journal of the Bulgarian Society of Endocrinology

How to treat?