Issue 1/2006

Issue: 1/2006 Author: G. Bocheva, B. Bocheva, S. Zacharieva, N. Boyadjieva Abstract:  The skin is commonly affected in thyroid diseases, but the mechanism of thyroid-associated dermatopathy is still unclear. The thyrotropin receptor, known also as thyroid-stimulating hormone receptor (TSH-R) may play a role in skin changes. It is possible that TSH-R expressed in the skin may […]

Issue: 1/2006 Author: S. Vladeva, D. Terzieva, D. Arabadjiska Abstract:  Clinical research clarifies the status of trace element selenium in the course of type 2 diabetes mellitus. thirty-one diabetics were studied and they were divided into groups with good and not sufficient glycaemic control when the duration of the disease was up to and over 5 […]

Issue: 1/2006 Author: Boyan Nonchev, Ivanka Sirakova, Dora Tersieva, Vladimir Danev, Nonka Mateva Abstract:  OBJECTIVE: The aim of the present study was to evaluate the significance of the preoperative thyroid autoantibody titers (TSHR-Abs; TPOAbs; TG-Abs) for the development of hypothyroidism after subtotal thyroidectomy in patients with Graves’ disease.   PATIENTS AND METHODS: 71 patients with Graves’ […]

Issue: 1/2006 Author: Mаria Yaneva, Georgi Kirilov, Krassimir Kalinov and Sabina Zacharieva Abstract:  The aim of the study was to assess the diagnsotic value of midnight salivary cortisol determination as a screening method for Cushing’s syndorme (CS). A fully automated highly sensitive electrochemiluminescence immunoassay (ECLIA) was used to measure salivary cortisol. Three groups were studied: 20 […]

Issue: 1/2006 Author: Mаria Yaneva, Atanaska Elenkova, Krassimir Kalinov, Georgi Kirilov, Sabina Zacharieva Abstract:  The present study includes patients with Cushing’s syndrome (CS) (n=13), with obesity as a part of the metabolic syndrome (MS) (n=17) and healthy subjects with normal body weight (n=14). The aim is to investigate the effect of Desmoprerssin (DDAVP) and to evaluate […]

Issue: 1/2006 Author: M. Hristova, I. Boncheva Abstract:  Recent evidence suggests that chronic stress (distress) increases the production of the cytokines interleukin (IL)-1 and tumor necrosis factor-α (TNF-α) by cells of the immune system and hypothalamus.   Psychological stress also upregulates the synthesis and secretion of the neurotrophin nerve growth factor (NGF) by the submandibular glands, […]

Issue: 1/2006 Author: Alexander T. Popov Abstract:  The diversity of names for the two major types of diabetes demonstrate the difficulty in drawing a clear separating line between them. The faceless numeric signature we have been using recently is a definite confirmation. The two types of diabetes pertain to different pathologic domains: type 1 is an […]