Issue 3/2010

Acromegaly in Bulgaria – Epidemiological Characteristics Derived from the National Acromegaly Database

Issue: 3/2010 Author: S. Vandeva, M. Andreeva, M. Orbetsova, D. Charakciev, G. Krilov, A. Elenkova, I. Atanasova, E. Nachev, M. Yaneva, Ph. Kumanov, A. Tomova, M. Marinov, K. Kalinov, K. Hristozov, Z. Kamenov, J. Gerenova, I. Tsinlikov, S. Zacharieva Abstract: Acromegaly is a chronic syndrome, due to growth hormone (GH) hypersecretion. Epidemiological characteristics could be evaluated […]

Serum sFas and sFasL Levels in Patients with Type 2 Diabetes Mellitus and Arterial Hypertension

Issue: 3/2010 Author: N. Stoynev, G. Kirilov, T. Tankova Abstract:  Aim: The aim of this study is to evaluate serum sFas and sFasL levels in patients with type 2 diabetes mellitus and hypertension and to compare with normotensive type 2 diabetic patients. Material and methods: Ninety four type 2 diabetic patients (54 males and 40 females), […]

Genotype-Phenotype Correlations in Familial Pheochromocytomas

Issue: 3/2010 Author: А. Еlenkova, X. Jeunemaitre, AP Gimenez-Roqueplo, К. Hristozov, S. Zacharieva Abstract: Germline mutations in RET proto-oncogene, VHL gene and the genes encoding SDHB, SDHD and SDHC subunits of succinate dehydrogenase are responsible for approximately 30% of all pheochromocytomas. Most importantly, according to literature data, 12-24% of patients with an apparently sporadic pheochromocytoma (ASP) […]

Underestimated Danger: Cobalamin Deficiency in Type 2 Diabetes Mellitus

Issue: 3/2010   Author: Prof. Dragomir Koev Abstract:  Cobalamin is an essential biomolecule containing cobalt, entering the human body with food and by means of different transporters reaching the cells. There it binds to cellular receptors and activates certain biochemical reactions. It is essential mostly for the normal chemopoiesis and for the integrity of the nervous […]

Statins and Osteoporosis

Issue: 3/2010 Author: Lyudmila Vladimirova-Kitova, Fedya Nikolov, Ganet Mineva, Maria Orbetzova Abstract:  There is an increased body of evidence in the medical literature concerning the pleiotropic effects of statins – e.g. effects beyond the lipid lowering actions of these drugs. The later include improvement of different pathological conditions including osteoporosis. It is believed that statins have […]

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Journal of the Bulgarian Society of Endocrinology

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