Issue 4/2010

Syndromes of Reduced Sensitivity to Thiroid Hormone Genettic Defects in Hormone Receptors, Gell Transporters and Deiodination

Issue: 4/2010 Author: Samuel Refetoff and Alexandra M. Dumitrescu Abstract: At least six major steps are required for secreted thyroid hormone (TH) to exert its action on target tissues. Mutations interfering with three of these steps have been so far identified and are the subject of this communication. The first recognized defect, causing resistance to TH, […]


Ghrelin – Role in the Regulation of Body Weight, Metabolic and Reproductive Disturbances

Issue: 4/2010 Author: Maria Orbetzova, Mitko Mitkov, Blagovest Pehlivanov Abstract: Ghrelin has profound orexigenic, adipogenic, and somatotropic properties, increasing food intake and body weight. Secreted predominantly from the stomach, ghrelin is the natural ligand for the growth hormone secretagogue- receptor (GHS-R) in the pituitary gland, thus fulfilling the criteria of a brain–gut peptide. The brain–gut axis […]


A Case With Thyrotoxic Cardiomyopathy and ECGImaging Resembling an Acute Coronary Syndrome

Issue: 4/2010 Author: Boyan Lozanov, G. Gergelcheva, D.Dimov, G. Lazarova and I. Gasharova Abstract: Thyrotoxic cardiomyopathy is a severe complication of hyperthyroidism. The hormonal excess may provoke a severe cardio-pulmonary failure in result of different dystrophic and functional lesions including coronary symptom/signs. The case described here concerns to a femail aged 52 yr with history of […]


Serum Levels of TNF-alpha and Non-alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Patients with Metabolic Syndrome

Issue: 4/2010 Author: Julieta Gerenova, Irena Manolova, Hristo Georgiev, Zahari Nikitov Abstract: Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome (MetS), is consistently associated with obesity and type 2 diabetes mellitus (DM). Adipose tissue produces a number of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha). The objective of this study was […]


Endocrinologia bg-flag

Journal of the Bulgarian Society of Endocrinology

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