Hyperinsulinemia and its Relationship with Hyperlipidemia and Counter-regulatory Hormones in Patients Surviving Myocardial Infarction

Clinic of Endocrinology, University of Nis, Serbia, Yugoslavia

 

Abstract: 

The association between free fasting plas¬ma insulin level and myocardial infaction, as well as the correlation of insulin level with hyperlipi¬demia and the level of counterregulatory hor¬mones was studied in 24 patients surviving myocardial infarction but with no history data of diabetes mellitus and in 18 patients with history of non-insulin dependent diabetes mellitus. The results of the patients surviving myocardial infarc¬tion were compared between the first and seventh day of hospitalization. Non-diabetic patients had higher insulin at first and seventh day of surviving of myocardial infarction. Analysing the correlation between insulin and plasma lipids, positive corre-lation was found between insulin and cholesterol, LDL-cholesterol, triglycerides, prebeta lipoproteins and especially high correlation with apoprotein В level, but negative with the level of HDL and HDI-2-cholesterol as well as with apoprotein A level. Analysing the level of free fasting insulin with the level of counterregulatory hormones, higher positive correlation was found with TSH, but negative with Cortisol level in spite of its increase during myocardial infarction. The results obtained indicated that hyperinsulinemia could not be excluded as a possible risk factor for ath-erosclerosis and coronary disease, but most probably it may be a factor that could influence other risk factors especially plasma lipoprotein metabolism.

 

Keywords: hyperinsulinemia, myocar­dial  infarction,  non-insulin dependent diabetes.