Diabetic Cardiomyopathy – a Diagnostic Challenge in Endocrinological Practice (a Review with Own Data)
Author: Gorcheva, Desislava I., Lozanov, Lachezar B.
Abstracts:
The increasing rate of obesity and immobility among the population has contributed to an increase in the incidence of type 2 diabetes mellitus (DM2) and related cardiovascular diseases (CVD). Despite the new therapeutic options and the change in the overall antidiabetic treatment approach in the last decade, cardiovascular diseases remain a challenge in its treatment. It is known that heart failure (HF) is one of the main cardiovascular (CV) complications and cause of death in patients with DM2. Diabetic cardiomyopathy (DCM) is a serious, often underestimated CV complication of diabetes occurring in the absence of other CV diseases and leading initially to clinically apparent heart failure with preserved left ventricular ejection fraction (HFpEF). Chronic hyperglycemia and hyperinsulinemia, along with insulin resistance and an inflammatory environment, are the main mechanisms involved in the pathophysiology of DCM. Early diagnosis of DCM in patients with DM2 will limit the progression of this often undetected diabetic complication to fatal HF and death. This review with own data aims to present a brief update on the challenges in the diagnostic process of diabetic cardiomyopathy and the possibilities for its prevention.
