Is There a Use for the Combination of Tetra-iodothyronine (Thyroxine, T4 ) and Triiodothyronine (T3 ) in the Replacement Treatment of Hypothyroidism?
Author: Boyanov, Mihail A. 1, Boyanova, Mira E. 2
Abstracts:
Hypothyroidism is one of the common en docrine diseases. Its established treatment in volves only various forms of levothyroxine (T4). Regardless of achieving normal levels of thyroid hormones with optimal doses of levothyroxine, a significant proportion of patients continue to have unexplained complaints and report a reduced quality of life. Attempts to find an individualized formula for the treatment of hypothyroidism, in cluding a small dose of triiodothyronine (T3), have been ongoing for many decades. Interest in combined T4 /T3 treatment experiences high and low tides of scientific and practical interest.
This review focuses on some aspects of levothyroxine treatment and on the alternative views offered in recent years about the place of combined T4 /T3 therapy in a very small proportion of patients. The opinions of the leading experts in. Europe were used as a basis. Practical approaches to switching to such treatment are outlined. At tention has been drawn to the fact that informed consent from the patient is necessary for the application of suchnon-traditional schemes. Isolated treatment with T3 or dried extracts is strictly not recommended. In conclusion, adherence to the guidelines for good clinical practice established in the country and the algorithms of the NHF guar antees sustainable results and a legal basis for the replacement treatment in hypothyroidism.
