Casus: Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma – the way to Diagnosis
Author: Raykov, Nikolay I.1, Raykova, Asya N.2, Avdzhiyska, Milena G.3, Vicheva, Snezhinka V.4, Hristova, Valentina D.5, Kuzmanov, Samuil Ya.6, Babev, Petar L.6, Chaushev, Borislav G.7, Kachovski, Tsvetomir E.8, Raykov, Miroslav N.9
2. MBAL “Dobrich”, Dobrich, First Department of Internal Diseases
3. Medical University, Varna, Bulgaria
4. Oncology Dispensary “Marko Markov”, Varna, Department of Clinical Pathology
5. MBAL “St. Anna”, Varna, Department of Clinical Pathology
6. MBAL “St. Anna”, Varna, Department of Breast Surgery
7. UMHAT “St. Marina”, Varna, Nuclear Medicine Clinic
8. Medical Unievrsity, Varna, Department of Obstetrics and Gynaecology
9. MBAL “St. Anna”, Varna, Department of Orthopedics and Traumatology
Abstract: Papillary thyroid cancer (PTC) is the most common type of malignancy of the endocrine system. First described in 1985, diffuse sclerosing papillary carcinoma of the thyroid (DSVPTC) is a rare variant of PTC. The prevalence of DSVPTC varies from 0,7–6,6% of all papillary thyroid carcinoma and tends to occur more frequently in young patients. It involves the whole thyroid gland and neck lymph nodes. Typical ultrasonographic features of this tumor are abundant diffuse microcalcifications and hypoechogenicity and diffuse fibrosis of the thyroid parenchyma. Fibrosis and lymph infiltration are typical for autoimmune thyroiditis too and should be differentiated from this variant of PTC. If this disease is diagnosed early and treated aggressively then normal life expectancy is unaffected.
Key words: diffuse sclerosing variant of papillary thyroid carcinoma, thyroid ultrasonography, fine needle biopsy
