Non-insulin dependent diabetes mellitus and hypertension – the role of insulin resistance and hyperinsulinemia
Issue: 3/1997
Author: V. Ivanov, Military Medical Academy – Department of endocrinology, Sofia
The syndrome hyperinsulinemia /insulin resistance is the main component of the so called syndrome X, defined by Reaven in 1988. The present survey discusses the role of insulin resistance and hyperinsulinemia in NIDDM and arterial hypertension. Attention is drawn to the causes and mechanisms for developing Insulin resistance and the influence of genetic factors, determining insulin resistance is underlined as well as that of metabolic factors – bradykinins, parathyroid hypertensive factor, calcium-magnesium metabolism, sodium-hydrogen and sodium-lithium transport.
Finally we reach the conclusion that in the pathogenetic aspect arterial hypertension and non-insulin dependent diabetes mellitus are intlimately related and this specific relation is the insulin resistance and hyperinsulinemia.
Keywords: non-insulin dependent diabetes mellitus, hypertension, insulin resistance, hyperinsulinemia.
