Metabolic and Atherogenic Parameters in Women with Metabolic Syndrome and Metabolically Healthy Overweight/Obese Women
Issue: 2/2017
Author: Koleva, Daniela Iv.1, Orbetzova, Maria M.
1 Clinic/Department of Endocrinology and metabolic diseases, “Sv. Georgy” University Hospital, Medical Faculty, Medical University, Plovdiv
Abstract:
Patients with metabolic syndrome (MS) are characterized by an increased risk of cardiovascular disease (CVD) development due to the presence of a cluster of risk factors such as visceral adiposity, different degrees of glucose tolerance impairment, atherogenic dyslipidemia and arterial hypertension. There has been a great increase in MS prevalence in the last few decades leading to а parallel growth of general population risk of CVD occurrence.
The aim of the study was to assess the risk factors for the development of type 2 diabetes mellitus (T2DM) and CVD based on a comparative analysis of glucose and lipid metabolism parameters as well as calculated atherogenic indices/ratios in women with established MS and metabolically healthy overweight/obese women (MHO).
Materials and methods: The study comprised of 52 women with MS (mean age of 37,75±11,38 years and with mean BMI − 34,64±4,81 kg/m2 ) and 22 age and BMI matched metabolically healthy overweight/obese women (mean age of 35,27±9,09 years and with mean BMI − 35,09±3,23 kg/m2 ). The following measurements and laboratory tests were conducted in all the participants: weight, height, waist and hip circumferences, oral glucose tolerance test (OGTT) with blood samples for glucose (GLU) and insulin (IRI) measurements obtained 0, 60 and 120 minutes after oral 75 g glucose administration, serum levels of total cholesterol (TC), HDL-C, triglycerides (TG). LDL-C values were determined using the Friedewald equation = {TC – (HDL-C+TG/2,2)}. Body mass index (BMI)=weight(kg)/height(m)2 , waist-hip-ratio (WHR), homeostasis model assessment insulin resistance index (HOMA-IR)=(GLU0′ x IRI0′)/22,5), Castelli risk indices I (TC/HDL-C) and II (LDL-C/HDL-C), TG/HDL-C and atherogenic index of plasma (AIP) = {(logTG)/HDL-C} were calculated.
Results: Comparable values of age and anthropometric parameters were determined in the two investigated groups of women. Significantly higher levels of fasting and stimulated GLU and IRI as well as HOMA-IR values were evaluated in MS women compared to those in MHO women. We found significantly higher serum levels of TG and values of TC/HDL-C, TG/HDL-C and AIP in women with MS compared to MHO women. Serum HDL-C levels were established to be significantly lower in MS participants.
Conclusion: Higher levels of basal and stimulated GLU and IRI, values of HOMA-IR and atherogenic indices/ratios showed a higher risk of T2DM and CVD development in women with metabolic syndrome compared to metabolically healthy overweight/obese women.
Key words: metabolically healthy obesity, blood glucose, insulin,atherogenic indices/ratios
