Peroxidized Lipids and Oxidative Stress Evaluation in Acromegalic Patients
Issue: 1/2002
Abstract:
Acromegaly is chracterized by enhanced turnover of lipid metabolism which explains the surge of interest in studies on peroxidated lipid product in acromegalic patients.
Serum levels of total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and total thiobarbituric acid reacting substances (TBARS) as well as HDL-fraction TBARS and LDL-fraction TBARS, are determined in 19 acromegaly patients. Total antioxidative capacity of serum (TAOCS), superoxide dismutase (SOD), SH-groups and ceruloplasmine levels are evaluated as an index for oxidative assessment. Twenty healthy age-matched subjects serve as controls.
The values of total serum cholesterol, triglycerides and LDL-cholesterol levels are significantly higher in acromegaly patients. Total serum TBARS levels among patients (1,46 ± 0,31 nmol/l) are lower than the ones in controls (2,70 ± 0,65 nmol/l) at p < 0,001, as well as HDK-fracion TBARS in patients (0,84 ± 0,56 nmol/l) and healthy subjects (1,41 ± 0,55 nmol/l), p < 0,01. The LDL-fraction TBARS is likewise lower in acromegaly patients (0,62 ± 0,59 nmol/l), as compared to controls (1,73 ± 0,89 nmol/l), p < 0,001. In healthy controls the HDL-cholesterol is 29% of the total serum cholesterol, whereas in patients it is 17% only. In contrast, the HDL-fraction TBARS in acromegaly is 58% of total serum TBARS, and 52% in the controls. Analogical but more clearcut changes are established in patients with active disease by comparison with the total group.
In conclusion, as shown by the results, there is a reduction of peroxidized lipid serum products in the group of patients, as compared to controls. In acromegaly patients the changes in TAOCS, ceruloplasmine, SOD, SH groups' level point to a situation of oxidative stress.
Keywords: acromegaly, peroxidized lipids, oxidative stress.
