Radionuclide Angiography before and after Treatment with Sulodexide in Patients Presenting Diabetes and Peripheral Macroangiopathy

Author: A. Klisarova*, H. Bohchelian, L. Koeva, Medical University – Varna, Clinic of Endocrinology, *Department of Radiology

 

Abstract: 

 

The aim of the study is to assay Sulodexide (Vessel Due F) effect on the parameters of radionuclide angiography with 99mTc-MDP in diabetics with peripheral vascular disease. Fifteen patients presenting diabetes type 2 and peripheral macroangiopathy (stage Il according to Fontaine) are covered by the study. It is designed as a longitudinal prospective study, undertaken after objaining informed consent and against the background of adequate glycemic control. Sulodexide is administrated im for ten days at dose 600 lipoproteinlipase releasing units (LSU), followed by 500 LSU per os for further 60 days. Before and after treatment, radionuclide angiography with 99mTc-MDP is carried out along with analysis of the angiographic parameters of the perfusion curves. An increase in the amplitude of post-treatment perfusion curves is established. Sulodexide (Vessel Due F) treatment is practicable in the complex theraupetic approach to patients presenting peripheral diabetic macroangiopathy.

 

Keywords: radionuclide angiography, Sulodexide, diabetes, macroangiopathy.