Could COVID-19 be a Causative Factor for Hyperglycaemia and Cause Diabetes Mellitus

Author: Todorova, Katya N., Tsvetkova, Victoria Ts.

Clinic of Endocrinology and Diseases of Metabolism,
“Dr. G. Stranski” University Hospital, Medical University, Pleven



Since the outbreak of the COVID-19 pandemic, it has been suspected that its causative agent, the SARS-CoV-2 coronavirus, may cause transient or permanent hyperglycemia. This fact has resulted in a new focus of research interest related to the study of potential mechanisms leading to damage of pancreatic insulinproducing cells, as well as the possible impact of the virus on insulin sensitivity, which may manifest as metabolic disturbances in patients with COVID-19 and cause diabetes mellitus. Evidence from the literature suggests that Corona viruses can damage pancreatic β-cells by direct or indirect mechanisms and cause changes in insulin secretion and sensitivity. To what extent all these changes are valid claims that SARS-CoV-2 can trigger diabetes mellitus is still not fully proven.

Key words: SARS-CoV-2, COVID- 19, diabetes mellitus, pancreatic β-cell dysfunction, insulin resistance

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Journal of the Bulgarian Society of Endocrinology

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